Axon guidance in the vertebrate central nervous system

Curr Opin Genet Dev. 1991 Aug;1(2):230-5. doi: 10.1016/s0959-437x(05)80075-9.


The development of connections in the central nervous system depends on the ability of the tips of growing axons to find their appropriate, often distant, target field. Factors that regulate axon outgrowth may be distinct from those that influence direction finding. Tissue culture methods have helped to distinguish between possible in vivo mechanisms and, in some cases, have identified candidate molecules.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Central Nervous System / embryology*
  • Cerebral Cortex / embryology
  • Embryonic Induction
  • Embryonic and Fetal Development
  • Growth Substances / physiology
  • Morphogenesis
  • Pons / embryology
  • Retina / embryology
  • Retinal Ganglion Cells / cytology
  • Superior Colliculi / embryology
  • Vertebrates / embryology*


  • Growth Substances