Prevention of adhesion formation following ovarian surgery in a standardized animal model: comparative study of Interceed and double layer Surgicell

J Obstet Gynaecol Res. 2008 Feb;34(1):12-7. doi: 10.1111/j.1447-0756.2007.00684.x.


Aim: Comparison of antiadhesive performances of double layer Surgicell and single layer Interceed following ovarian surgery in a rabbit model.

Methods: Prospective randomized controlled trial performed at the animal laboratory of a university. Thirty-nine New Zealand White female rabbits of reproductive age were included. Ovaries were bivalved with a no. 15 scalpel. One of the ovaries was covered with a single layer of Interceed while the other was covered with a double layer of Surgicell. In the control group no adhesion barriers were used. Four weeks later adhesions were scored macroscopically. Following oophorectomy specimens were evaluated microscopically for mesothelial proliferation. The macroscopic adhesion score according to Blauer's criteria and the number of mesothelial cell layers were compared.

Results and conclusion: The control group had significantly higher adhesion scores than the barrier groups. Macroscopic adhesion scores were not different among the barrier groups. The average number of mesothelial cell layers was 1.77+/-2.68, 1.69+/-2.58 (range 0-8) and 2.04+/-2.84 (range 0-10) for ovaries in the control, Interceed and Surgicell groups, respectively: the difference was not significant. Our results demonstrate that a double layer of Surgicell is as effective as Interceed in reducing postoperative adhesion formation in a rabbit model.

MeSH terms

  • Animals
  • Cellulose, Oxidized / administration & dosage*
  • Disease Models, Animal
  • Female
  • Hemostatics / administration & dosage*
  • Ovarian Diseases / physiopathology
  • Ovarian Diseases / prevention & control*
  • Ovary / pathology
  • Ovary / surgery*
  • Postoperative Complications / physiopathology
  • Postoperative Complications / prevention & control*
  • Prostheses and Implants
  • Rabbits
  • Tissue Adhesions / physiopathology
  • Tissue Adhesions / prevention & control*
  • Wound Healing


  • Cellulose, Oxidized
  • Hemostatics