Trends in demographic and clinical characteristics in women diagnosed with corpus cancer and their potential impact on the increasing number of deaths

Am J Obstet Gynecol. 2008 Feb;198(2):218.e1-6. doi: 10.1016/j.ajog.2007.08.075.

Abstract

Objective: The purpose of this study was to determine factors responsible for the increasing number of deaths from corpus cancer over three time periods.

Study design: Data were collected from the Surveillance, Epidemiology and End Results database from 1988-2001. Kaplan-Meier and Cox proportional hazards regression analyses were performed.

Results: Of 48,510 women with corpus cancer, there was an increase in the proportion of patients dying from advanced cancers (52.1% to 56.0% to 68.8%; P < .001), grade 3 disease (47.5% to 53.3% to 60.6%; P < .001), serous tumors (14.3% to 18.4% to 16.6%; P < .001), and sarcomas (19.1% to 20.4% to 27.2%; P < .001) over time. On multivariate analysis, older age, African American race, lack of primary staging procedures, advanced-stage, high-grade, and non-endometrioid histology were independent prognostic factors for worse survival.

Conclusion: Our data suggest that the increase in mortality in women with corpus cancer over the last 14 years may be related to an increased rate of advanced-stage cancers and high-risk histologies.

MeSH terms

  • Adenocarcinoma, Clear Cell / epidemiology
  • Adenocarcinoma, Clear Cell / etiology
  • Adenocarcinoma, Clear Cell / mortality
  • Carcinoma, Endometrioid / epidemiology
  • Carcinoma, Endometrioid / etiology
  • Carcinoma, Endometrioid / mortality
  • Carcinoma, Papillary
  • Databases, Factual
  • Demography
  • Female
  • Humans
  • Middle Aged
  • Mortality / trends
  • Neoplasm Staging
  • Risk Factors
  • SEER Program
  • Sarcoma / epidemiology
  • Sarcoma / etiology
  • Sarcoma / mortality
  • Survival Analysis
  • United States / epidemiology
  • Uterine Neoplasms / epidemiology*
  • Uterine Neoplasms / etiology
  • Uterine Neoplasms / mortality