Abstract
A series of conjugates combining a pyrimidine and a quinolone moiety were designed and synthesized. The assay results show that these compounds demonstrate both anti-RT activity and anti-IN activity and therefore provide a useful scaffold for identifying inhibitors with balanced dual activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacology
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HIV Integrase Inhibitors / chemical synthesis*
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HIV Integrase Inhibitors / pharmacology
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HIV Reverse Transcriptase / antagonists & inhibitors*
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Pyrimidines / chemical synthesis*
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Pyrimidines / chemistry
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Pyrimidines / pharmacology
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Quinolones / chemical synthesis
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Quinolones / chemistry*
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Quinolones / pharmacology
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Reverse Transcriptase Inhibitors / chemical synthesis*
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Reverse Transcriptase Inhibitors / pharmacology
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Structure-Activity Relationship
Substances
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Anti-HIV Agents
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HIV Integrase Inhibitors
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Pyrimidines
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Quinolones
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Reverse Transcriptase Inhibitors
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HIV Reverse Transcriptase