Possible role of oxidative stress in the pathogenesis of hypertension

Diabetes Care. 2008 Feb:31 Suppl 2:S181-4. doi: 10.2337/dc08-s245.


Recently oxidative stress has been proposed as the cause of hypertension. An imbalance in superoxide and nitric oxide production may account for reduced vasodilation, which in turn can favor the development of hypertension. In vitro and in human studies support this hypothesis. The supplementation of antioxidants, particularly in the form of fresh fruit and vegetables, reduces blood pressure, supporting a role for free radicals in hypertension.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antihypertensive Agents / therapeutic use*
  • Antioxidants / therapeutic use*
  • Diabetic Angiopathies / drug therapy
  • Diabetic Angiopathies / epidemiology
  • Diabetic Angiopathies / etiology*
  • Diabetic Angiopathies / physiopathology*
  • Humans
  • Hypertension / drug therapy
  • Hypertension / epidemiology
  • Hypertension / etiology*
  • Hypertension / physiopathology*
  • Incidence
  • NADP / metabolism
  • Oxidative Stress / physiology*
  • Reactive Oxygen Species / metabolism


  • Antihypertensive Agents
  • Antioxidants
  • Reactive Oxygen Species
  • NADP