Hereditary etiologies of hypomagnesemia

Nat Clin Pract Nephrol. 2008 Feb;4(2):80-9. doi: 10.1038/ncpneph0680.

Abstract

Magnesium ions are essential to all living cells. As the second most abundant intracellular cation, magnesium has a crucial role in fundamental metabolic processes such as DNA and protein synthesis, oxidative phosphorylation, enzyme function, ion channel regulation, and neuromuscular excitability. After presenting an overview of magnesium homeostasis, we review the etiologies of hypomagnesemia, with an emphasis on hereditary causes.

Publication types

  • Review

MeSH terms

  • Biological Transport
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / physiopathology
  • Diabetes Mellitus / etiology
  • Diabetes Mellitus / physiopathology
  • Education, Medical, Continuing
  • Female
  • Genetic Predisposition to Disease*
  • Homeostasis / physiology
  • Humans
  • Hypertension / etiology
  • Hypertension / physiopathology
  • Hypocalcemia / blood
  • Hypocalcemia / diagnosis*
  • Kidney Diseases / etiology
  • Kidney Diseases / physiopathology
  • Magnesium / metabolism*
  • Magnesium Deficiency / blood
  • Magnesium Deficiency / genetics*
  • Male
  • Prognosis
  • Protein-Serine-Threonine Kinases
  • Risk Assessment
  • TRPM Cation Channels / genetics*
  • TRPM Cation Channels / metabolism

Substances

  • TRPM Cation Channels
  • TRPM6 protein, human
  • Protein-Serine-Threonine Kinases
  • TRPM7 protein, human
  • Magnesium