Genetic imprinting of H19 and IGF2 in domestic pigs (Sus scrofa)

Anim Biotechnol. 2008;19(1):22-7. doi: 10.1080/10495390701758563.


The genes insulin-like growth factor 2 (IGF2) and H19 express paternally and maternally, respectively, in humans, mice, sheep, and cattle. Additionally, IGF2 has been shown to be regulated by at least four promoters in a tissue- or development-specific manner. In the domestic pigs, the promoter- and tissue-specific imprinting pattern of IGF2 has not been well characterized, nor is the imprinting pattern of H19. In the present study, we identified two polymorphisms in each of IGF2 (exons 2 and 9) and H19 (exons 1 and 5) and determined the imprinting status of these two genes in 13 organs / tissues of week-old pigs. IGF2 P1 transcript is bi-allelically expressed (not imprinted) in all major organs studied, while the majority of IGF2 transcripts are expressed from promoters 2-4 and are imprinted. H19 is exclusively expressed from the maternal allele in all major organs, concurrent with observations in other species.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Genome
  • Genomic Imprinting*
  • Insulin-Like Growth Factor II / genetics*
  • Male
  • Polymorphism, Genetic
  • RNA, Long Noncoding
  • RNA, Untranslated / genetics*
  • Semen / cytology
  • Semen / physiology
  • Skin / cytology
  • Swine / genetics*


  • H19 long non-coding RNA
  • RNA, Long Noncoding
  • RNA, Untranslated
  • Insulin-Like Growth Factor II