Tuberculosis exposure in HIV-exposed infants in a high-prevalence setting

Int J Tuberc Lung Dis. 2008 Feb;12(2):225-7.


Exposure to TB was quantified by screening human immunodeficiency virus (HIV) exposed infants aged 3-4 months for an isoniazid prophylaxis study where tuberculosis (TB) exposure excluded enrolment. Seventy-seven (10.1%, 95%CI 8.0-12.4) of 766 infants had contact with a TB source case. Nurses and lay counsellors identified 52 infants during pre-screening and doctors identified 25 during formal screening. High exposure may contribute to high rates of TB in HIV-exposed infants. Programs to prevent mother-to-child transmission of HIV offer an important opportunity to screen for TB. In-depth assessment is required for evaluating TB exposure.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • HIV Infections / epidemiology*
  • HIV Infections / transmission
  • Humans
  • Infant
  • Infectious Disease Transmission, Vertical
  • Mass Screening*
  • Maternal Health Services
  • Pregnancy
  • Pregnancy Complications, Infectious / epidemiology
  • Prevalence
  • South Africa / epidemiology
  • Tuberculosis, Pulmonary / epidemiology
  • Tuberculosis, Pulmonary / prevention & control*