Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels

Physiol Genomics. 2008 Mar 14;33(1):26-32. doi: 10.1152/physiolgenomics.00174.2007. Epub 2008 Jan 29.


Laboratory inbred mouse strains show a broad range of variation in phenotypes, such as body composition, bone mineral density (BMD), plasma leptin, and insulin-like growth factor I (IGF-I), and thus provide a basis for the study of associations among them. We analyzed these phenotypes in male and female mice from 43 inbred strains fed on a high-fat (30% caloric content) diet and from 30 inbred strains fed on a low-fat (6%) diet. Structural equation modeling of these data reveals that the relationship of body fat content and areal BMD is altered by dietary factors and genotypes. Sex has no net effect on areal BMD, but after accounting for body mass difference females have higher areal BMD. Leptin is affected by relative fat mass and has no net effect on areal BMD. IGF-I has a direct effect on areal BMD.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Body Composition / drug effects*
  • Bone Density / drug effects*
  • Diet, Atherogenic
  • Dietary Fats / pharmacology*
  • Female
  • Insulin-Like Growth Factor I / physiology
  • Leptin / blood
  • Leptin / physiology
  • Male
  • Mice
  • Mice, Inbred Strains / blood
  • Mice, Inbred Strains / physiology*
  • Models, Biological
  • Sex Factors


  • Dietary Fats
  • Leptin
  • Insulin-Like Growth Factor I