Occupation and lymphoid malignancies: results from a French case-control study

J Occup Environ Med. 2007 Dec;49(12):1339-50. doi: 10.1097/JOM.0b013e3181569a49.

Abstract

Objectives: Investigating relationships between potential occupational risk factors and lymphoid malignancy (LM).

Methods: We conducted a multicenter hospital-based case-control study in France between 2000 and 2004, including 824 incident cases of non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), multiple myeloma, and "lymphoproliferative syndrome" and 752 frequency-matched controls. Data were collected through face-to-face standardized and detailed interviews.

Results: Farming was significantly associated with NHL (odds ratio [OR] = 1.4 [1.0 to 2.0]) and, although not significantly, with lymphoproliferative syndrome and multiple myeloma. ORs were higher for longest durations of exposure. Self-declared exposure to pesticides was significantly associated with NHL (OR = 1.8 [1.2 to 2.7]) and HL (OR = 2.2 [1.0 to 4.7]). Neither solvent-related jobs nor self-reported exposure to solvents were related to LM. Systematic screening based on job titles did not evidence any other association.

Conclusions: The results support the hypothesis that farming plays a role in most types of LM.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Employment / statistics & numerical data
  • Female
  • France / epidemiology
  • Humans
  • Incidence
  • Lymphoma / epidemiology*
  • Male
  • Middle Aged
  • Multiple Myeloma / epidemiology*
  • Occupational Exposure / statistics & numerical data*
  • Occupations / statistics & numerical data*
  • Risk Factors