Classifying the expansion kinetics and critical surface dynamics of growing cell populations

Phys Rev Lett. 2007 Dec 14;99(24):248101. doi: 10.1103/PhysRevLett.99.248101. Epub 2007 Dec 10.

Abstract

We systematically study the growth kinetics and the critical surface dynamics of cell monolayers by a class of computationally efficient cellular automaton models avoiding lattice artifacts. Our numerically derived front velocity relationship indicates the limitations of the Fisher-Kolmogorov-Petrovskii-Piskounov equation for tumor growth simulations. The critical surface dynamics corresponds to the Kardar-Parisi-Zhang universality class, which disagrees with the interpretation by Bru et al. of their experimental observations as generic molecular-beam-epitaxy-like growth, questioning their conjecture that a successful therapy should lead away from molecular beam epitaxy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis
  • Cell Adhesion
  • Cell Communication
  • Cell Cycle*
  • Cell Growth Processes*
  • Cell Movement
  • Models, Biological*