Meta-analysis of risk for relapse to substance use after transplantation of the liver or other solid organs

Liver Transpl. 2008 Feb;14(2):159-72. doi: 10.1002/lt.21278.


For patients receiving liver or other organ transplants for diseases associated with substance use, risk for relapse posttransplantation is a prominent clinical concern. However, there is little consensus regarding either the prevalence or risk factors for relapse to alcohol or illicit drug use in these patients. Moreover, the evidence is inconsistent as to whether patients with pretransplantation substance use histories show poorer posttransplantation medical adherence. We conducted a meta-analysis of studies published between 1983 and 2005 to estimate relapse rates, rates of nonadherence to the medical regimen, and the association of potential risk factors with these rates. The analysis included 54 studies (50 liver, 3 kidney, and 1 heart). Average alcohol relapse rates (examined only in liver studies) were 5.6 cases per 100 patients per year (PPY) for relapse to any alcohol use and 2.5 cases per 100 PPY for relapse with heavy alcohol use. Illicit drug relapse averaged 3.7 cases per 100 PPY, with a significantly lower rate in liver vs. other recipients (1.9 vs. 6.1 cases). Average rates in other areas (tobacco use, immunosuppressant and clinic appointment nonadherence) were 2 to 10 cases per 100 PPY. Risk factors could be examined only for relapse to any alcohol use. Demographics and most pretransplantation characteristics showed little correlation with relapse. Poorer social support, family alcohol history, and pretransplantation abstinence of < or =6 months showed small but significant associations with relapse (r = 0.17-0.21). Future research should focus on improving the prediction of risk for substance use relapse, and on testing interventions to promote continued abstinence posttransplantation.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol-Related Disorders / epidemiology*
  • Alcohol-Related Disorders / psychology
  • Behavior, Addictive*
  • Heart Transplantation / statistics & numerical data
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Kidney Transplantation / statistics & numerical data
  • Liver Transplantation / statistics & numerical data*
  • Organ Transplantation / statistics & numerical data*
  • Patient Compliance
  • Recurrence
  • Risk Assessment
  • Risk Factors
  • Smoking / epidemiology
  • Social Support
  • Substance-Related Disorders / epidemiology*
  • Substance-Related Disorders / psychology
  • Temperance
  • Time Factors


  • Immunosuppressive Agents