The STAR*D study: treating depression in the real world

Cleve Clin J Med. 2008 Jan;75(1):57-66. doi: 10.3949/ccjm.75.1.57.


The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study evaluated feasible treatment strategies to improve clinical outcomes for real-world patients with treatment-resistant depression. Although the study found no clear-cut "winner", it does provide guidance on how to start therapy and how to proceed if initial treatment fails.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Algorithms
  • Antidepressive Agents / therapeutic use*
  • Citalopram / therapeutic use
  • Clinical Trials as Topic*
  • Depression / drug therapy*
  • Depression / therapy
  • Disease Progression
  • Humans
  • Treatment Outcome*


  • Antidepressive Agents
  • Citalopram