In Australia the most important preventable causes of cancer, in order of importance, are tobacco smoking, diet, obesity, sunlight exposure, alcohol consumption and occupational exposure to carcinogens. We review and discuss these causes and their potential preventability and discuss three broad strategies in cancer prevention: public health policy and legislation, screening, and education and behavior change. In each of these broad areas, current research evidence and relevant approaches to research and development are considered. Six areas of research and development priority for cancer prevention and education are suggested: cigarette smoking (particularly among children and adolescents); protection of the skin from exposure to strong sunlight; screening; dietary choices; occupational exposures; and the social and environmental context of cancer prevention. All of these strategies and concerns will not apply to every country in the Asia-Pacific region but may be useful as guidelines and as a stimulus for determining particular local priorities.