Fibrinogen gamma' in ischemic stroke: a case-control study

Stroke. 2008 Mar;39(3):1033-5. doi: 10.1161/STROKEAHA.107.495499. Epub 2008 Jan 31.


Background and purpose: To determine the contribution of fibrinogen gamma' levels and FGG haplotypes to ischemic stroke.

Methods: Associations between fibrinogen gamma' levels, fibrinogen gamma'/total fibrinogen ratio, and FGG haplotypes with the risk of ischemic stroke were determined in 124 cases and 125 controls.

Results: Fibrinogen gamma'/total fibrinogen ratio was higher in patients than in controls during the acute phase of the stroke and lower in the convalescent phase 3 months after the stroke. FGG haplotype 3 (H3) was associated with a reduced risk of ischemic stroke (odds ratio 0.60; 95% CI, 0.38 to 0.94), but not with the fibrinogen gamma'/total fibrinogen ratio. In contrast, FGG-H2 was associated with a decreased fibrinogen gamma'/total fibrinogen ratio, but not with risk of stroke.

Conclusions: Fibrinogen gamma'/total fibrinogen ratio is associated with ischemic stroke, especially in the acute phase of the disease. In addition, FGG-H3 haplotype appears to be protective against ischemic stroke.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Brain Ischemia / complications*
  • Case-Control Studies
  • Female
  • Fibrinogens, Abnormal / metabolism*
  • Genetic Variation
  • Haplotypes
  • Heterozygote
  • Humans
  • Ischemic Attack, Transient / blood
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Stroke / blood*
  • Stroke / etiology*
  • Stroke / prevention & control


  • Fibrinogens, Abnormal
  • fibrinogen gamma'