Short-term DTI predictors of cognitive dysfunction in mild traumatic brain injury

Brain Inj. 2008 Feb;22(2):115-22. doi: 10.1080/02699050801888816.


Primary objective: To explore whether baseline diffusion tensor imaging (DTI) metrics are predictive of cognitive functioning 6 months post-injury in patients with mild traumatic brain injury (MTBI).

Research design: Seventeen patients with MTBI and 29 sex- and age-matched healthy controls were studied.

Methods and procedures: Participants underwent an MRI protocol including DTI, at an average of 4.0 (range: 1-10) days post-injury. Mean diffusivity (MD) and fractional anisotropy (FA) were measured in the following white matter (WM) regions: centra semiovale, the genu and the splenium of the corpus callosum and the posterior limb of the internal capsule. Participants underwent neuropsychological (NP) testing at baseline and at 6-month follow-up. Least squares regression analysis was used to evaluate the association of MD and FA with each NP test score at baseline and follow-up.

Main outcomes and results: Compared to controls, average MD was significantly higher (p = 0.02) and average FA significantly lower (p = 0.0001) in MTBI patients. At the follow-up, there was a trend toward a significant association between baseline MD and response speed (r = -0.53, p = 0.087) and a positive correlation between baseline FA and Prioritization form B (r = 0.72, p = 0.003).

Conclusions: DTI may provide short-term non-invasive predictive markers of cognitive functioning in patients with MTBI.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Brain / pathology
  • Brain Injuries / complications*
  • Case-Control Studies
  • Cognition Disorders / diagnosis*
  • Diffusion Magnetic Resonance Imaging / methods*
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Predictive Value of Tests