DNA promoter hypermethylation in saliva for the early diagnosis of oral cancer

J Calif Dent Assoc. 2007 Dec;35(12):844-9.

Abstract

Oral health care professionals could drastically improve the quality of life for patients with potentially malignant oral lesions by using a noninvasive test that could be used to detect cancer using saliva. Promoter DNA hypermethylation is a critical step in oral carcinogenesis and has a number of significant advantages over genetic and protein diagnostic markers. Methylight is a recently developed assay that rapidly quantifies promoter hypermethylation and could potentially be applied into a clinical setting.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Biomarkers, Tumor / analysis*
  • Cadherins / genetics
  • Cyclin-Dependent Kinase Inhibitor p15 / genetics
  • DNA Methylation*
  • DNA Modification Methylases / genetics
  • DNA Repair Enzymes / genetics
  • Early Diagnosis
  • Genes, APC
  • Genes, p16
  • Humans
  • Mouth Mucosa / pathology
  • Mouth Neoplasms / diagnosis*
  • Mouth Neoplasms / genetics
  • Mouth Neoplasms / pathology
  • Promoter Regions, Genetic / genetics*
  • Protein Kinase Inhibitors / analysis
  • Saliva / chemistry*
  • Tumor Suppressor Proteins / genetics

Substances

  • Biomarkers, Tumor
  • Cadherins
  • Cyclin-Dependent Kinase Inhibitor p15
  • Protein Kinase Inhibitors
  • Tumor Suppressor Proteins
  • DNA Modification Methylases
  • MGMT protein, human
  • DNA Repair Enzymes