Insulin resistance and lipid levels in adolescents with familial risk for psychosis

Acta Psychiatr Scand. 2008 May;117(5):337-41. doi: 10.1111/j.1600-0447.2008.01154.x. Epub 2008 Jan 30.


Objective: Type 2 diabetes and dyslipidemias co-occur frequently with schizophrenia. It is not known how common they are in adolescents with a familial risk for psychosis.

Method: The Northern Finland 1986 Birth Cohort consists of 9432 children born alive in the two Northernmost provinces in Finland. At the age of 15/16 they participated in clinical examination including measurements of glucose, lipids and IR, and a questionnaire including items about their diet and physical activity. The Finnish Hospital Discharge Register was used to find out non-organic psychoses in parents during 1972-2000. This familial risk was found out in 54 boys and 68 girls. Their results were compared with other cohort members.

Results: No differences were observed in the cardiometabolic risk factors between the study groups.

Conclusion: Our results suggest that familial risk for psychosis is not directly associated with disturbances of glucose and lipid metabolism among adolescents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Blood Glucose / analysis
  • Catchment Area, Health
  • Child
  • Cholesterol / blood*
  • Female
  • Finland / epidemiology
  • Follow-Up Studies
  • Humans
  • Insulin Resistance / physiology*
  • Male
  • Mothers
  • Prospective Studies
  • Psychotic Disorders* / blood
  • Psychotic Disorders* / epidemiology
  • Psychotic Disorders* / genetics
  • Risk Factors
  • Sex Factors
  • Surveys and Questionnaires


  • Blood Glucose
  • Cholesterol