Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ob mice

Neurosci Lett. 2008 Mar 12;433(2):82-6. doi: 10.1016/j.neulet.2007.12.051. Epub 2007 Dec 28.


Leptin modulates multiple ion channels making its net effect on brain excitability difficult to predict. One method of determining leptin's net effect on brain excitability is to examine brain excitability during chronic leptin deficiency. We compared the susceptibility of leptin deficient ob/ob and wild type mice to pentylenetetrazol (PTZ) induced seizures using continuous video electroencephalogram (EEG) recordings. We found that ob/ob mice were more likely to die and were more susceptible to generalized clonic and clonic-tonic seizures than wild type mice at submaximal PTZ doses. These findings suggest that chronic leptin deficiency in vivo increases seizure susceptibility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Dose-Response Relationship, Drug
  • Electroencephalography
  • Leptin / deficiency*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Obese
  • Pentylenetetrazole*
  • Reaction Time / drug effects
  • Seizures / chemically induced
  • Seizures / genetics
  • Seizures / physiopathology*
  • Severity of Illness Index


  • Leptin
  • Pentylenetetrazole