Structural insights shed light onto septin assemblies and function

Curr Opin Cell Biol. 2008 Feb;20(1):12-8. doi: 10.1016/ Epub 2008 Jan 31.


While the original septin mutants were identified more than 30 years ago for their role in cytokinesis [Hartwell, LH: Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis. Exp Cell Res 1971, 69: 265-276], the architecture of septin complexes and higher order structures has remained a mystery up until very recently. Over the last few months a number of converging approaches have suddenly provided a wealth of structural information about the different levels of septin organization. Here, we review these advancements and highlight their functional consequences.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Models, Molecular
  • Phosphoric Monoester Hydrolases / chemistry*
  • Phosphoric Monoester Hydrolases / metabolism*
  • Phosphoric Monoester Hydrolases / ultrastructure
  • Protein Structure, Quaternary
  • Protein Subunits / chemistry
  • Protein Subunits / metabolism


  • Protein Subunits
  • Phosphoric Monoester Hydrolases