Discovery of Novel FMS Kinase Inhibitors as Anti-Inflammatory Agents

Bioorg Med Chem Lett. 2008 Mar 1;18(5):1642-8. doi: 10.1016/j.bmcl.2008.01.059. Epub 2008 Jan 19.

Abstract

The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC(50)=0.0008 microM) served as a proof-of-concept candidate in a collagen-induced model of arthritis in mice.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacology*
  • Arthritis / chemically induced
  • Arthritis / drug therapy
  • Collagen
  • Dose-Response Relationship, Drug
  • Mice
  • Models, Molecular
  • Molecular Structure
  • Receptor, Macrophage Colony-Stimulating Factor / antagonists & inhibitors*
  • Structure-Activity Relationship
  • Time Factors

Substances

  • Anti-Inflammatory Agents
  • Collagen
  • Receptor, Macrophage Colony-Stimulating Factor