Mitochondria--a nexus for aging, calorie restriction, and sirtuins?

Cell. 2008 Jan 25;132(2):171-6. doi: 10.1016/j.cell.2008.01.007.


Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria, and sirtuins might interact in a pathway to slow aging and associated diseases.

Publication types

  • Review

MeSH terms

  • Aging*
  • Animals
  • Caloric Restriction*
  • Humans
  • Mitochondria / physiology*
  • Models, Biological
  • Sirtuins*


  • Sirtuins