Dubbing SAGA unveils new epigenetic crosstalk

Mol Cell. 2008 Feb 1;29(2):152-4. doi: 10.1016/j.molcel.2008.01.007.

Abstract

In a recent issue of Molecular Cell, two independent studies (Zhang et al., 2008; Zhao et al., 2008) provide compelling evidence that targeted deubiquitylation of histones is intimately linked to transcription activation, epigenetic regulation, and cancer progression.

Publication types

  • Comment

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Animals, Genetically Modified
  • Cell Line
  • Conserved Sequence
  • Drosophila Proteins / chemistry
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / metabolism
  • Endopeptidases / chemistry
  • Endopeptidases / genetics
  • Endopeptidases / metabolism
  • Gene Silencing*
  • Heterochromatin / genetics
  • Heterochromatin / metabolism*
  • Histone Acetyltransferases / chemistry
  • Histone Acetyltransferases / genetics
  • Histone Acetyltransferases / metabolism*
  • Humans
  • Molecular Sequence Data
  • Multiprotein Complexes / chemistry
  • Multiprotein Complexes / genetics
  • Multiprotein Complexes / metabolism
  • Promoter Regions, Genetic / genetics
  • Protein Interaction Mapping
  • RNA Polymerase II / genetics
  • RNA Polymerase II / metabolism
  • Receptors, Androgen / genetics
  • Receptors, Androgen / metabolism
  • Recombinant Fusion Proteins / genetics
  • Recombinant Fusion Proteins / metabolism
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Thiolester Hydrolases / chemistry
  • Thiolester Hydrolases / physiology
  • Trans-Activators / chemistry
  • Trans-Activators / metabolism*
  • Transcription Factors / chemistry
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcription Factors, General / chemistry
  • Transcription Factors, General / genetics
  • Transcription Factors, General / metabolism*
  • Transcription, Genetic / physiology
  • Ubiquitin Thiolesterase
  • Ubiquitination / physiology*
  • p300-CBP Transcription Factors / chemistry
  • p300-CBP Transcription Factors / genetics
  • p300-CBP Transcription Factors / metabolism

Substances

  • ATXN7L3 protein, human
  • Drosophila Proteins
  • Eny2 protein, human
  • Heterochromatin
  • Multiprotein Complexes
  • Receptors, Androgen
  • Recombinant Fusion Proteins
  • Sgf11 protein, Drosophila
  • Trans-Activators
  • Transcription Factors
  • Transcription Factors, General
  • e(y)2 protein, Drosophila
  • Histone Acetyltransferases
  • p300-CBP Transcription Factors
  • p300-CBP-associated factor
  • RNA Polymerase II
  • Thiolester Hydrolases
  • Endopeptidases
  • not protein, Drosophila
  • Ubiquitin Thiolesterase
  • Usp22 protein, human