Rare dipeptide and urea derivatives from roots of Moringa oleifera as potential anti-inflammatory and antinociceptive agents

Eur J Med Chem. 2009 Jan;44(1):432-6. doi: 10.1016/j.ejmech.2007.12.018. Epub 2007 Dec 28.


In the course of our studies on the isolation of bioactive compounds from the roots of Moringa oleifera, a traditional herb in southeast Asia, rare aurantiamide acetate 4 and 1,3-dibenzyl urea 5 have been isolated and characterized. And also, this is the first report of isolation from this genus. Isolated compound inhibited the production of TNF-alpha and IL-2; further compound 5 showed significant analgesic activities in a dose dependant manner. These findings may help in understanding the mechanism of action of this traditional plant leading to control of activated mast cells on inflammatory conditions like arthritis, for which the crude extract has been used.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / chemical synthesis*
  • Analgesics / pharmacology
  • Animals
  • Anti-Inflammatory Agents / chemical synthesis*
  • Anti-Inflammatory Agents / pharmacology
  • Dipeptides / chemical synthesis*
  • Dipeptides / pharmacology
  • Interleukin-2 / antagonists & inhibitors
  • Mast Cells / drug effects
  • Moringa oleifera / chemistry*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry
  • Rats
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Urea / chemical synthesis*
  • Urea / pharmacology


  • Analgesics
  • Anti-Inflammatory Agents
  • Dipeptides
  • Interleukin-2
  • Plant Extracts
  • Tumor Necrosis Factor-alpha
  • Urea