Innate immunity phenotypic features point toward simultaneous raise of activation and modulation events following 17DD live attenuated yellow fever first-time vaccination

Vaccine. 2008 Feb 26;26(9):1173-84. doi: 10.1016/j.vaccine.2007.12.035. Epub 2008 Jan 14.


Detailed multiparametric phenotypic investigation aiming to characterize the kinetics of the innate immune response in the peripheral blood following 17DD yellow fever (17DD-YF) first-time vaccination was performed. Results showed increased frequency of monocytes and NK cell subpopulations besides unexpected up-regulation of granulocytes activation status (CD28+/CD23+ and CD28+/HLA-DR+, respectively). Up-regulation of Fcgamma-R and IL-10-R expression emerge as putative events underlying the mixed pattern of phenotypic features triggered by the 17DD yellow fever (17DD-YF) vaccination. Mixed pattern of chemokine receptors expression further support our hypothesis that a parallel establishment of activation/modulation microenvironment plays a pivotal role in the protective immunity triggered by the 17DD-YF vaccine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Granulocytes / immunology
  • Humans
  • Immunity, Innate*
  • Killer Cells, Natural / immunology
  • Male
  • Middle Aged
  • Monocytes / immunology
  • Receptors, IgG / metabolism
  • Receptors, Interleukin-10 / metabolism
  • Up-Regulation
  • Vaccination
  • Vaccines, Attenuated* / administration & dosage
  • Vaccines, Attenuated* / immunology
  • Yellow Fever / immunology*
  • Yellow Fever / prevention & control
  • Yellow Fever Vaccine* / administration & dosage
  • Yellow Fever Vaccine* / immunology
  • Yellow fever virus / immunology*


  • Receptors, IgG
  • Receptors, Interleukin-10
  • Vaccines, Attenuated
  • Yellow Fever Vaccine