Host-guest interaction of L-tyrosine with beta-cyclodextrin

Spectrochim Acta A Mol Biomol Spectrosc. 2008 Nov 1;71(1):125-32. doi: 10.1016/j.saa.2007.10.054. Epub 2007 Nov 29.


The inclusion complexes of beta-cyclodextrin (beta-CD) with L-tyrosine (L-TYN) were investigated by using spectrophotometers. The absorption and fluorescence enhancement occurs with beta-CD and L-TYN forms 1:1 inclusion complex. The unusual blue shift of hydroxyl ion in the beta-CD medium confirms OH groups present in the interior part of the beta-CD cavity and -COOH group present in the upper part of the beta-CD cavity. A mechanism is proposed to explain inclusion process. The inclusion interaction was examined and the thermodynamic parameters of inclusion process DeltaG, DeltaH and DeltaS were determined. The results indicated that the inclusion process was an exergonic and spontaneous process. Stable solid inclusion complexes were established and characterized by FT-IR, scanning electron microscope (SEM) methods.

MeSH terms

  • Crystallization
  • Hydrogen-Ion Concentration
  • Hydroxyl Radical / chemistry
  • Ions
  • Microscopy, Electron, Scanning
  • Models, Chemical
  • Oxygen / chemistry
  • Powders
  • Protein Binding
  • Spectrometry, Fluorescence / methods
  • Spectrophotometry / methods
  • Spectroscopy, Fourier Transform Infrared
  • Thermodynamics
  • Tyrosine / chemistry*
  • beta-Cyclodextrins / chemistry*


  • Ions
  • Powders
  • beta-Cyclodextrins
  • Hydroxyl Radical
  • Tyrosine
  • betadex
  • Oxygen