The ygaVP genes of Escherichia coli form a tributyltin-inducible operon

Appl Environ Microbiol. 2008 Mar;74(6):1954-8. doi: 10.1128/AEM.02294-07. Epub 2008 Feb 1.


A tributyltin (TBT) luxAB transcriptional fusion in Escherichia coli revealed that a TBT-activated promoter is located upstream of two cotranscribed orphan genes, ygaV and ygaP. We demonstrate that transcription from the promoter upstream of ygaVP is constitutive in a ygaVP mutant, suggesting that YgaV is an autoregulated, TBT-inducible repressor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acid Anhydride Hydrolases / genetics
  • Amino Acid Sequence
  • Escherichia coli / genetics*
  • Escherichia coli Proteins / genetics*
  • Gene Expression Regulation, Bacterial / drug effects*
  • Molecular Sequence Data
  • Mutation
  • Operon*
  • Polymerase Chain Reaction
  • Promoter Regions, Genetic / genetics
  • Repressor Proteins / genetics*
  • Sequence Homology, Amino Acid
  • Transcription, Genetic / drug effects
  • Trialkyltin Compounds / pharmacology*


  • Escherichia coli Proteins
  • Repressor Proteins
  • Trialkyltin Compounds
  • YgaP protein, E coli
  • YgaV protein, E coli
  • tributyltin
  • Acid Anhydride Hydrolases
  • RppH protein, E coli