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. 2008 Feb;121(2):e260-8.
doi: 10.1542/peds.2006-3766.

Baby Care Products: Possible Sources of Infant Phthalate Exposure


Baby Care Products: Possible Sources of Infant Phthalate Exposure

Sheela Sathyanarayana et al. Pediatrics. .


Objectives: Phthalates are man-made chemicals found in personal care and other products. Recent studies suggest that some phthalates can alter human male reproductive development, but sources of infant exposure have not been well characterized. We investigated the relationship between phthalate metabolite concentrations in infant urine and maternal reported use of dermally applied infant care products.

Methods: We measured 9 phthalate metabolites in 163 infants who were born in 2000-2005. An infant was considered to have been exposed to any infant care product that the mother reported using on her infant within 24 hours of urine collection. Results of multiple linear regression analyses are reported as the ratio of metabolite concentrations (with 95% confidence intervals) in exposed and unexposed infants. We standardized concentrations by forming z scores and examined combined exposure to multiple metabolites.

Results: In most (81%) infants, > or = 7 phthalate metabolites were above the limit of detection. Exposure to lotion was predictive of monoethyl phthalate and monomethyl phthalate concentrations, powder of monoisobutyl phthalate, and shampoo of monomethyl phthalate. Z scores increased with number of products used. Most associations were stronger in younger infants.

Conclusions: Phthalate exposure is widespread and variable in infants. Infant exposure to lotion, powder, and shampoo were significantly associated with increased urinary concentrations of monoethyl phthalate, monomethyl phthalate, and monoisobutyl phthalate, and associations increased with the number of products used. This association was strongest in young infants, who may be more vulnerable to developmental and reproductive toxicity of phthalates given their immature metabolic system capability and increased dosage per unit body surface area.

Comment in

  • Baby care products.
    Postellon DC. Postellon DC. Pediatrics. 2008 Jun;121(6):1292; author reply 1292-3. doi: 10.1542/peds.2008-0401. Pediatrics. 2008. PMID: 18519505 No abstract available.
  • Baby products and phthalates.
    Bailey J. Bailey J. Pediatrics. 2008 Sep;122(3):674-5; author reply 675. doi: 10.1542/peds.2008-1311. Pediatrics. 2008. PMID: 18762539 No abstract available.

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