Inhibitory effects of hypertonic saline on P. aeruginosa motility

J Cyst Fibros. 2008 Jul;7(4):267-269. doi: 10.1016/j.jcf.2007.11.009. Epub 2008 Jan 31.


Salt transport defects in CF lungs predispose to overwhelming and fatal respiratory infection caused by Pseudomonas aeruginosa. Motility of this organism is central to pathogenesis in a number of settings. Incubation of numerous strains of P. aeruginosa with hypertonic saline caused a concentration-dependent decrease in bacterial motility. Reduction of P. aeruginosa virulence through this effect may contribute to clinical efficacy of hypertonic saline aerosols in CF patients.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Anti-Infective Agents / pharmacology*
  • Biofilms / drug effects
  • Chemotaxis / drug effects
  • Cystic Fibrosis / complications
  • Cystic Fibrosis / drug therapy*
  • Flagella / drug effects*
  • Humans
  • Pseudomonas Infections / complications
  • Pseudomonas Infections / prevention & control
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / physiology
  • Respiratory Tract Infections / complications
  • Respiratory Tract Infections / prevention & control
  • Saline Solution, Hypertonic / pharmacology*


  • Anti-Infective Agents
  • Saline Solution, Hypertonic