Selective versus total insulin resistance: a pathogenic paradox

Cell Metab. 2008 Feb;7(2):95-6. doi: 10.1016/j.cmet.2007.12.009.


Mice with type 2 diabetes manifest selective hepatic insulin resistance: insulin fails to suppress gluconeogenesis but continues to activate lipogenesis, producing the deadly combination of hyperglycemia and hypertriglyceridemia. In this issue of Cell Metabolism, Biddinger et al. (2008) show that mice with total hepatic insulin resistance exhibit hyperglycemia without hypertriglyceridemia-a state paradoxically less severe than selective insulin resistance.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2
  • Gluconeogenesis
  • Hyperglycemia / etiology
  • Hypertriglyceridemia / etiology
  • Insulin / physiology
  • Insulin Resistance*
  • Liver Diseases
  • Mice


  • Insulin