Conserved metabolic regulatory functions of sirtuins

Cell Metab. 2008 Feb;7(2):104-12. doi: 10.1016/j.cmet.2007.11.006.


Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to humans. Their dependence on nicotinamide adenine dinucleotide (NAD+) links their activity to cellular metabolic status. In bacteria, the sirtuin CobB regulates the metabolic enzyme acetyl-coenzyme A (acetyl-CoA) synthetase. The earliest function of sirtuins therefore may have been regulation of cellular metabolism in response to nutrient availability. Recent findings support the idea that sirtuins play a pivotal role in metabolic control in higher organisms, including mammals. This review surveys evidence for an emerging role of sirtuins as regulators of metabolism in mammals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetate-CoA Ligase / metabolism
  • Animals
  • Bacteria
  • Humans
  • Metabolism*
  • NAD / metabolism
  • Sirtuins / physiology*


  • NAD
  • Sirtuins
  • Acetate-CoA Ligase