Free radicals and antioxidants in inflammatory processes and ischemia-reperfusion injury

Vet Clin North Am Small Anim Pract. 2008 Jan;38(1):31-123, v. doi: 10.1016/j.cvsm.2007.11.008.


This article discusses the current understanding of the role of free radicals and antioxidants in inflammatory processes and in ischemia reperfusion injury. It begins by describing the manifestations of acute inflammation and outlining the cellular events that occur during inflammation. It then describes the biochemical mediators of inflammation with special attention to nitric oxide. It details the process of hypoxia reperfusion injury, the enzymes involved, its treatment, and studies involving specific hypoxia reperfusion injuries in various animal species.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / metabolism*
  • Cats
  • Cattle
  • Dogs
  • Free Radicals / metabolism*
  • Horses
  • Hypoxia
  • Inflammation / metabolism*
  • Nitric Oxide / metabolism
  • Oxidation-Reduction
  • Oxidative Stress*
  • Reactive Oxygen Species / metabolism
  • Reperfusion Injury / metabolism*
  • Species Specificity


  • Antioxidants
  • Free Radicals
  • Reactive Oxygen Species
  • Nitric Oxide