Neuronal plasticity and functional recovery after ischemic stroke

Top Stroke Rehabil. 2008 Jan-Feb;15(1):42-50. doi: 10.1310/tsr1501-42.

Abstract

Ischemic stroke affects many new patients each year. The sequelae of brain ischemia can include lasting sensorimotor and cognitive deficits, which negatively impact quality of life. Currently, treatment options for improving poststroke deficits are limited, and the development of new clinical alternatives to improve functional recovery after stroke is actively under investigation. Anti-Nogo-A immunotherapy to reduce the central nervous system inhibitory environment, cell transplantation strategies, pharmacological agents, and movement-based therapies represent emerging treatments of poststroke deficits through enhancement of neuroanatomical plasticity.

Publication types

  • Review

MeSH terms

  • Aged
  • Animals
  • Brain Ischemia / complications*
  • Humans
  • Immunotherapy
  • Motion Therapy, Continuous Passive
  • Myelin Proteins / immunology
  • Neuronal Plasticity / drug effects
  • Neuronal Plasticity / physiology*
  • Nogo Proteins
  • Rats
  • Recovery of Function / physiology*
  • Stem Cell Transplantation
  • Stroke / etiology
  • Stroke / physiopathology*
  • Stroke / psychology
  • Stroke / therapy*
  • Stroke Rehabilitation*

Substances

  • Myelin Proteins
  • Nogo Proteins
  • RTN4 protein, human
  • Rtn4 protein, rat