Genome-wide Approaches to Studying Chromatin Modifications

Nat Rev Genet. 2008 Mar;9(3):179-91. doi: 10.1038/nrg2270.


Over two metres of DNA is packaged into each nucleus in the human body in a manner that still allows for gene regulation. This remarkable feat is accomplished by the wrapping of DNA around histone proteins in repeating units of nucleosomes to form a structure known as chromatin. This chromatin structure is subject to various modifications that have profound influences on gene expression. Recently developed techniques to study chromatin modifications at a genome-wide scale are now allowing researchers to probe the complex components that make up epigenomes. Here we review genome-wide approaches to studying epigenomic structure and the exciting findings that have been obtained using these technologies.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Chromatin / metabolism*
  • DNA Methylation
  • Epigenesis, Genetic*
  • Genome
  • Genomics*
  • Histone Code
  • Humans


  • Chromatin