PET kinetic analysis: error consideration of quantitative analysis in dynamic studies

Ann Nucl Med. 2008 Jan;22(1):1-11. doi: 10.1007/s12149-007-0083-2.


Positron emission tomography dynamic studies have been performed to quantify several biomedical functions. In a quantitative analysis of these studies, kinetic parameters were estimated by mathematical methods, such as a nonlinear least-squares algorithm with compartmental model and graphical analysis. In this estimation, the uncertainty in the estimated kinetic parameters depends on the signal-to-noise ratio and quantitative analysis method. This review describes the reliability of parameter estimates for various analysis methods in reversible and irreversible models.

Publication types

  • Review

MeSH terms

  • Algorithms*
  • Computer Simulation
  • Data Interpretation, Statistical
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Kinetics
  • Models, Biological*
  • Models, Statistical
  • Positron-Emission Tomography / methods*
  • Radioisotope Dilution Technique*
  • Reproducibility of Results
  • Sensitivity and Specificity