The effect of probiotics on Helicobacter pylori eradication

Hepatogastroenterology. 2007 Oct-Nov;54(79):2032-6.


Background/aims: Conflicting results have been reported on the effect of a variety of probiotic strains on Helicobacter pylori (HP) eradication. In this study, we evaluated the outcome of a probiotic strain composed of bacillus subtilis and Streptococcus faecium on HP eradication.

Methodology: We recruited 352 HP infected patients who were randomized into a triple-plus-probiotics group or a triple-only group; the participants received 1 week of PPI-based triple therapy with or without probiotics supplements. For the triple-plus-probiotics group, probiotics was continued for 8 weeks. All patients in the two groups were evaluated for 4 weeks after completion of therapy.

Results: Using the intention to treat analysis, evaluation of the triple-plus-probiotics group showed a higher eradication rate than the triple-only group (83.5% vs. 73.3%, p=0.027). Diarrhea and overall side effects were more common in the triple-only group (p<0.05).

Conclusions: Supplementation with probiotic strains, composed of Bacillus subtilis and Streptococcus faecium, were shown to improve drug compliance, reduce side effects and enhance the intention-to-treat eradication rate of HP.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Amoxicillin / therapeutic use
  • Anti-Bacterial Agents / therapeutic use
  • Bacillus subtilis*
  • Clarithromycin / therapeutic use
  • Drug Therapy, Combination
  • Enterococcus faecium*
  • Enzyme Inhibitors / therapeutic use
  • Female
  • Helicobacter Infections / prevention & control*
  • Helicobacter pylori*
  • Humans
  • Male
  • Middle Aged
  • Omeprazole / therapeutic use
  • Probiotics / therapeutic use*


  • Anti-Bacterial Agents
  • Enzyme Inhibitors
  • Amoxicillin
  • Clarithromycin
  • Omeprazole