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Review
, 368 (3), 455-7

Mature Adipocytes May Be a Source of Stem Cells for Tissue Engineering

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Review

Mature Adipocytes May Be a Source of Stem Cells for Tissue Engineering

M E Fernyhough et al. Biochem Biophys Res Commun.

Abstract

Adipose tissue contains a large portion of stem cells. These cells appear morphologically like fibroblasts and are primarily derived from the stromal cell fraction. Mature (lipid-filled) adipocytes possess the ability to become proliferative cells and have been shown to produce progeny cells that possess the same morphological (fibroblast-like) appearance as the stem cells from the stromal fraction. A closer examination of mature adipocyte-derived progeny cells may prove to be an emerging area of growth/metabolic physiology that may modify present thinking about adipose tissue renewal capabilities. Knowledge of these cells may also prove beneficial in cell-based therapies for tissue repair, regeneration, or engineering.

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