Relation of left ventricular function, mass, and volume to NT-proBNP in type 1 diabetic patients

Diabetes Care. 2008 May;31(5):968-70. doi: 10.2337/dc07-1536. Epub 2008 Feb 5.

Abstract

Objectives: To measure left ventricular mass (LVM), left ventricular volumes, and left ventricular function (LVF) in a cohort of type 1 diabetic patients and to correlate measures of imaging to NH(2)-terminal pro-brain natriuretic peptide (NT-proBNP).

Research design and methods: In a cross-sectional study, all patients with type 1 diabetes underwent cardiovascular magnetic resonance imaging. We included 63 patients with diabetic nephropathy and 73 patients with normoalbuminuria.

Results: All patients had normal global LVF. LVM was increased in patients with diabetic nephropathy compared with patients with persistent normoalbuminuria. Patients with nephropathy had smaller left ventricular volumes and increased levels of NT-proBNP. Linear regression analysis in patients with diabetic nephropathy showed that NT-proBNP and creatinine were associated with LVM.

Conclusions: Increased LVM is identified in asymptomatic type 1 diabetic patients with nephropathy compared with normoalbuminuric patients. Elevated levels of NT-proBNP were associated with increased LVM, which are both markers of increased cardiovascular risk.

MeSH terms

  • Adult
  • Age of Onset
  • Albuminuria
  • Body Mass Index
  • Creatinine / blood
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / physiopathology*
  • Diabetic Nephropathies / blood
  • Diabetic Nephropathies / physiopathology*
  • Female
  • Glomerular Filtration Rate
  • Glycated Hemoglobin A / metabolism
  • Heart Ventricles / anatomy & histology*
  • Heart Ventricles / physiopathology*
  • Humans
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain / blood*
  • Peptide Fragments / blood*
  • Ventricular Function, Left*

Substances

  • Glycated Hemoglobin A
  • Peptide Fragments
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain
  • Creatinine