Abstract
Chemotherapy by direct hepatic arterial infusion (HAI) results in reduction in tumor mass in a large percentage of patients. The authors reviewed records for 45 patients with metastatic cancer of the gastrointestinal tract who underwent HAI chemotherapy with floxuridine, administrated via an implanted pump. Twenty-seven of the 45 patients suffered complications, including gastrointestinal ulceration (18%), hepatitis (24%), sclerosing cholangitis (7%), and abscess (2%). The complication rates in this series were similar to those previously reported. The toxicity of HAI chemotherapy continues to limit its efficacy.
MeSH terms
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Aged
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Chemical and Drug Induced Liver Injury / diagnostic imaging
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Chemical and Drug Induced Liver Injury / etiology
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Cholangitis, Sclerosing / chemically induced
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Cholangitis, Sclerosing / diagnostic imaging
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Female
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Floxuridine / administration & dosage*
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Floxuridine / adverse effects
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Floxuridine / therapeutic use
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Gastrointestinal Diseases / chemically induced
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Gastrointestinal Diseases / diagnostic imaging
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Gastrointestinal Diseases / etiology
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Gastrointestinal Neoplasms / pathology
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Hepatic Artery*
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Humans
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Infusion Pumps, Implantable*
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Infusions, Intra-Arterial / adverse effects*
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Liver Abscess / diagnostic imaging
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Liver Abscess / etiology
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Liver Neoplasms / drug therapy
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Liver Neoplasms / secondary
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Male
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Middle Aged
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Retrospective Studies
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Tomography, X-Ray Computed