Early radiation effects on tongue function for patients with nasopharyngeal carcinoma: a preliminary study

Dysphagia. 2008 Jun;23(2):193-8. doi: 10.1007/s00455-007-9128-x. Epub 2008 Feb 6.


The purpose of this study was to investigate early radiation effects on tongue function for patients with nasopharyngeal carcinoma (NPC) and to provide a scientific database for early intervention plans. Twelve subjects with NPC and 12 age- and sex-matched normal subjects were included. Tongue maximum isometric strength and endurance at 50% of maximum strength were obtained once from normal subjects with the Iowa Oral Performance Instrument (IOPI) and twice from the NPC subjects: before and 2 months after radiation treatment. No significant differences were found in tongue function evaluation for normal or NPC groups in either pre- or post-treatments. However, this study showed that significant decreases in tongue function may not start until 2 months after treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Squamous Cell / pathology*
  • Carcinoma, Squamous Cell / radiotherapy*
  • Deglutition Disorders / diagnosis*
  • Deglutition Disorders / etiology*
  • Deglutition Disorders / physiopathology
  • Female
  • Humans
  • Isometric Contraction
  • Male
  • Middle Aged
  • Nasopharyngeal Neoplasms / pathology*
  • Nasopharyngeal Neoplasms / radiotherapy*
  • Neoplasm Staging
  • Pharyngeal Muscles / physiopathology
  • Pharyngeal Muscles / radiation effects
  • Radiotherapy / adverse effects*
  • Time Factors