The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer

Cancer Metastasis Rev. 2008 Jun;27(2):169-78. doi: 10.1007/s10555-008-9125-z.


Although the aberrant actions of protein kinases have long been known to contribute to tumor promotion and carcinogenesis, roles for protein phosphatases in the development of human cancer have only emerged in the last decade. In this review, we discuss the data obtained from studies examining the biological and pathological roles of a serine/threonine protein phosphatase, PP5, which suggest that PP5 is a potentially important regulator of both hormone- and stress-induced signaling networks that enable a cell to respond appropriately to genomic stress.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic*
  • Humans
  • Neoplasms / enzymology*
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / physiology*
  • Phosphoprotein Phosphatases / chemistry
  • Phosphoprotein Phosphatases / physiology*
  • Protein Structure, Quaternary
  • Signal Transduction / physiology*
  • Stress, Physiological / enzymology*


  • Nuclear Proteins
  • Phosphoprotein Phosphatases
  • protein phosphatase 5