Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration

Cochrane Database Syst Rev. 2008 Jan 23:(1):CD000253. doi: 10.1002/14651858.CD000253.pub2.


Background: Some observational studies have suggested that people who eat a diet rich in antioxidant vitamins (carotenoids, vitamins C and E) or minerals (selenium and zinc) may be less likely to develop age-related macular degeneration (AMD).

Objectives: The aim of this review was to examine the evidence as to whether or not taking vitamin or mineral supplements prevents the development of AMD.

Search strategy: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Group Trials Register) in The Cochrane Library (2007, Issue 3), MEDLINE (1966 to August 2007), SIGLE (1980 to 2005/03), EMBASE (1980 to August 2007), National Research Register (2007, Issue 3), AMED (1985 to January 2006) and PubMed (on 24 January 2006 covering last 60 days), reference lists of identified reports and the Science Citation Index. We contacted investigators and experts in the field for details of unpublished studies.

Selection criteria: We included all randomised trials comparing an antioxidant vitamin and/or mineral supplement (alone or in combination) to control. We included only studies where supplementation had been given for at least one year.

Data collection and analysis: Both review authors independently extracted data and assessed trial quality. Data were pooled using a fixed-effect model.

Main results: Three randomised controlled trials were included in this review (23,099 people randomised). These trials investigated alpha-tocopherol and beta-carotene supplements. There was no evidence that antioxidant vitamin supplementation prevented or delayed the onset of AMD. The pooled risk ratio for any age-related maculopathy (ARM) was 1.04 (95% CI 0.92 to 1.18), for AMD (late ARM) was 1.03 (95% CI 0.74 to 1.43). Similar results were seen when the analyses were restricted to beta-carotene and alpha-tocopherol.

Authors' conclusions: There is no evidence to date that the general population should take antioxidant vitamin and mineral supplements to prevent or delay the onset of AMD. There are several large ongoing trials. People with AMD should see the related Cochrane review "Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration" written by the same author.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Antioxidants / administration & dosage*
  • Dietary Supplements*
  • Humans
  • Macular Degeneration / prevention & control*
  • Minerals / administration & dosage*
  • Randomized Controlled Trials as Topic
  • Vitamins / administration & dosage*
  • alpha-Tocopherol / administration & dosage
  • beta Carotene / administration & dosage


  • Antioxidants
  • Minerals
  • Vitamins
  • beta Carotene
  • alpha-Tocopherol