Proton pump-inhibiting drugs, calcium homeostasis, and bone health

Nutr Rev. 2008 Feb;66(2):103-8. doi: 10.1111/j.1753-4887.2008.00015.x.


Proton pump inhibitors (PPIs) are commonly used drugs, several of which are available without a prescription. Two recent studies have demonstrated increased hip fracture rates associated with PPI use. Theoretically, PPIs could impair intestinal calcium absorption resulting in increased rates of bone loss and a greater risk of fragility fracture.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Bone Density / drug effects*
  • Bone Resorption
  • Bone and Bones / drug effects*
  • Bone and Bones / metabolism*
  • Calcium / metabolism*
  • Fractures, Bone / chemically induced
  • Fractures, Bone / epidemiology
  • Hip Fractures / chemically induced
  • Hip Fractures / epidemiology
  • Humans
  • Proton Pump Inhibitors / adverse effects*
  • Proton Pump Inhibitors / therapeutic use


  • Proton Pump Inhibitors
  • Calcium