Effect of red wine antioxidants and minor polyphenolic constituents on endothelial progenitor cells after physical training in mice

Int J Cardiol. 2008 May 23;126(2):295-7. doi: 10.1016/j.ijcard.2007.11.081. Epub 2008 Feb 5.


Circulating endothelial progenitor cells (EPCs) play a significant role in regeneration of damaged blood vessels. Levels and functional activities of EPCs are noticeable altered by risk factors for coronary heart disease (CHD) and compounds that can prevent or ameliorate EPC dysfunction are currently of special clinical interest. Here, we evaluate the effects of red wine (RW) on EPCs in C57BL/6J mice subjected to physical exercise. FACS computed counting showed a significant increase of EPC number (P<0.05) in mice after short-term supplementation with RW. VEGF serum concentration was significantly increased by physical training in the presence or absence of RW supplementation (P<0.001). These in vivo observations support previous in vitro observation of the beneficial effect of RW in the modulation of EPC levels.

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / administration & dosage*
  • Cell Proliferation / drug effects
  • Endothelial Cells / cytology
  • Endothelial Cells / drug effects*
  • Endothelial Cells / physiology
  • Flavonoids / administration & dosage*
  • Mice
  • Mice, Inbred C57BL
  • Phenols / administration & dosage*
  • Physical Conditioning, Animal / methods*
  • Polyphenols
  • Stem Cells / cytology
  • Stem Cells / drug effects*
  • Stem Cells / physiology
  • Wine*


  • Antioxidants
  • Flavonoids
  • Phenols
  • Polyphenols