Forgiveness of non-adherence to HIV-1 antiretroviral therapy

J Antimicrob Chemother. 2008 Apr;61(4):769-73. doi: 10.1093/jac/dkn020. Epub 2008 Feb 6.

Abstract

Superior adherence to HIV-1 antiretroviral therapy is a mainstay of successful HIV management. Studies performed in the early era of highly active antiretroviral therapy demonstrated the need for > or =95% adherence in order to achieve and sustain viral suppression. High rates of viral suppression have been observed at more moderate levels of adherence with newer antiretroviral regimens. The term 'forgiveness' is being used to describe the ability of a regimen to achieve and sustain viral suppression, despite suboptimal adherence. A variety of pharmacological, viral and host properties determine the level of forgiveness of any specific regimen. As the choice of treatment options continues to expand, forgiveness of non-adherence is likely to emerge as an increasingly important factor in therapeutic decision-making.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Anti-HIV Agents / pharmacokinetics
  • Anti-HIV Agents / pharmacology
  • Anti-HIV Agents / therapeutic use*
  • HIV Infections / drug therapy*
  • HIV-1 / drug effects*
  • Humans
  • Treatment Outcome
  • Treatment Refusal*

Substances

  • Anti-HIV Agents