Phylogenetically distinct hantaviruses in the masked shrew (Sorex cinereus) and dusky shrew (Sorex monticolus) in the United States

Am J Trop Med Hyg. 2008 Feb;78(2):348-51.

Abstract

A limited search for hantaviruses in lung and liver tissues of Sorex shrews (family Soricidae, subfamily Soricinae) revealed phylogenetically distinct hantaviruses in the masked shrew (Sorex cinereus) from Minnesota and in the dusky shrew (Sorex monticolus) from New Mexico and Colorado. The discovery of these shrew-borne hantaviruses, named Ash River virus and Jemez Springs virus, respectively, challenges the long-held dogma that rodents are the sole reservoir hosts and forces a re-examination of their co-evolutionary history. Also, studies now underway are aimed at clarifying the epizootiology and pathogenicity of these new members of the genus Hantavirus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Disease Reservoirs / virology
  • Hantavirus / classification*
  • Hantavirus / genetics*
  • Hantavirus / isolation & purification
  • Hantavirus Infections / veterinary*
  • Hantavirus Infections / virology
  • Liver / virology
  • Lung / virology
  • Phylogeny*
  • Reverse Transcriptase Polymerase Chain Reaction / veterinary
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Shrews / virology*
  • United States