Pregnancy-associated liver disorders

Dig Dis Sci. 2008 Sep;53(9):2334-58. doi: 10.1007/s10620-007-0167-9. Epub 2008 Feb 7.


Liver disorders associated with pregnancy include hyperemesis gravidarum (HG), intrahepatic cholestasis of pregnancy (ICP), preeclampsia, syndrome of hemolysis, elevated liver enzymes and low platelets (HELLP), and acute fatty liver of pregnancy (AFLP). These conditions are relatively common and unique to pregnancy and are more likely to occur at certain terms of gestation specific to each condition. They can be associated with significant maternal and fetal morbidity and mortality. Although managing such patients may be very challenging, spontaneous resolution of the disease occurs shortly after termination of the pregnancy, usually without hepatic sequellae. Early diagnosis and timely treatment is a key to therapeutic success. This article explores the clinical features, pathophysiology, and management of these disorders.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Cholestasis, Intrahepatic / diagnosis
  • Cholestasis, Intrahepatic / drug therapy
  • Cholestasis, Intrahepatic / physiopathology
  • Diagnosis, Differential
  • Fatty Liver / diagnosis
  • Fatty Liver / drug therapy
  • Fatty Liver / physiopathology
  • Female
  • HELLP Syndrome / diagnosis
  • HELLP Syndrome / drug therapy
  • HELLP Syndrome / physiopathology
  • Humans
  • Hyperemesis Gravidarum / diagnosis
  • Hyperemesis Gravidarum / drug therapy
  • Hyperemesis Gravidarum / physiopathology
  • Liver Diseases / diagnosis
  • Liver Diseases / drug therapy
  • Liver Diseases / physiopathology*
  • Pregnancy
  • Pregnancy Complications / diagnosis
  • Pregnancy Complications / drug therapy
  • Pregnancy Complications / physiopathology*