BRCA1/2 associated hereditary breast cancer

J Zhejiang Univ Sci B. 2008 Feb;9(2):85-9. doi: 10.1631/jzus.B0710617.


Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes, focusing on their relationship with hereditary breast cancers. BRCA1/2 associated hereditary breast cancers have unique features that differ from the general breast cancers, including alterations in cellular molecules, pathological bases, biological behavior, and a different prevention strategy. But the outcome of BRCA1/2 associated hereditary breast cancers still remains controversial; further studies are needed to elucidate the nature of BRCA1/2 associated hereditary breast cancers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis Regulatory Proteins
  • BRCA1 Protein / genetics*
  • BRCA1 Protein / physiology*
  • BRCA2 Protein / genetics*
  • BRCA2 Protein / physiology*
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / metabolism*
  • Disease Progression
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Genetic Diseases, Inborn
  • Genetic Predisposition to Disease*
  • Humans
  • Mutation
  • Prognosis


  • Apoptosis Regulatory Proteins
  • BLID protein, human
  • BRCA1 Protein
  • BRCA1 protein, human
  • BRCA2 Protein
  • BRCA2 protein, human