Immunisation of staff of a regional blood transfusion centre with a recombinant hepatitis B vaccine

J Infect. 1991 Jan;22(1):5-9. doi: 10.1016/0163-4453(91)90786-r.


Medical, nursing, laboratory and other staff of the Mersey Regional Blood Transfusion Centre at risk of acquiring hepatitis B were vaccinated against the virus with a recombinant vaccine. Altogether, 86% staff developed greater than 10 mIU/ml antibody to hepatitis B virus surface antigen after immunisation but the proportion was lower in older staff. After a further injection of vaccine was given to poor and non-responders the overall proportion responding rose to 93%. The difference in response between the sexes was significant. Women had a higher rate of response and, among those persons responding, women developed a higher concentration of antibody.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Antibodies, Viral / analysis
  • Female
  • Health Facilities
  • Health Workforce*
  • Hepatitis B / prevention & control*
  • Hepatitis B Vaccines
  • Hepatitis B virus / analysis
  • Humans
  • Male
  • Middle Aged
  • Sex Factors
  • Vaccination*
  • Vaccines, Synthetic / administration & dosage
  • Vaccines, Synthetic / immunology*
  • Viral Hepatitis Vaccines / administration & dosage
  • Viral Hepatitis Vaccines / immunology*


  • Antibodies, Viral
  • Hepatitis B Vaccines
  • Vaccines, Synthetic
  • Viral Hepatitis Vaccines