We examined 60 patients with arterial hypertension admitted to hospital during hypertensive crisis. Control group consisted of 30 patients with normal arterial pressure. We investigated parameters of cerebral blood flow with the method of transcranial dopplerography, content of NO and a row of cytokines (interleukin-6, interleukin-0, tumor necrosis factor) in blood serum during hypotensive therapy with inclusion of calcium antagonist amlodipine and cerebroprotector vinpocetine. After 12 weeks of hypotensive therapy we noted significant antihypertensive effect, improvement of parameters of cerebral blood flow, and elevation of NO content in all groups of studied persons most pronounced in patients receiving amlodipine as monotherapy or in combination with vinpocetine. Administration of vinpocetine in addition to hypotensive therapy is justified in patients with hypertensive disease, as this significantly improves blood flow in cerebral vessels. This appears as elevation of linear blood flow velocity, lowering of peripheral resistance and increase of content of NO in blood serum.